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Testo-Quench™ |
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A synergistic combination of
phytoantiandrogens designed to restore healthy hormone balance by calming and supporting the ideal
function of testosterone sensitive tissues. |
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Three Capsules Contain: |
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Testo-Quench™
Herbal Proprietary Blend |
2,160 mg |
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Saw Palmetto (berry, standardized to 25% fatty
acids), Fennel (Foeniculum vulgare,
seed), Urtica dioica (leaf, standardized to 1% plant silica), Ocimum sanctum (leaf), Trigonella foenum-graecum (seed)
and Pygeum africanum (bark,
standardized to 12% phytosterols) |
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Suggested
Use: |
3 daily
with food |
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Also See: |
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MORE INFORMATION on the
Constituents of Testo-Quench™ |
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ABOUT
Phytoantiandrogens: Phytoantiandrogens are a class of phyto-compounds that
decrease tissue sensitivity to androgens or decrease androgen activity,
predominantly through the action of 5-alpha-reductase
inhibition, which decreases conversion of testosterone to the more androgenic
dihydrotestosterone. Androgen excess symptoms have been observed in
Menopause Types® 3, 6, 9 & 12. Androgen excess disorders have
also been observed in polycystic ovary disease (PCO) and PCO-like syndrome,
which has a milder clinical presentation than PCO. Even though PCO & PCO-like
syndrome occur in young women, associated insulin resistance, lipid disorders
and cancer risks have also been observed, revealing that these factors are
not exclusively age related.♦ |
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Saw
Palmetto: Saw Palmetto (Serenoa repens)
is widely used for
the antiandrogenic properties attributed to it, which are most likely due to
the presence of beta-sitosterol, palmitic-acid and stearic-acid, all of which have 5-alpha-reductase
inhibiting activity. The anti-inflammatory properties that have
recently been noted in Serenoa Repens may be
associated with its beneficial properties.♦ |
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Fennel: Fennel (Foeniculum
vulgare) seed is a source of the antiandrogens palmetic acid and beta-sitosterol, active components
within many antiandrogenic herbs. The androgen antagonist
properties of Foeniculum vulgare have been used for women in topical agents
to control hirsutism. In animal studies, fennel extracts have demonstrated
antitumor activity in testosterone sensitive tissue.♦ |
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Nettles: Nettles (Urtica
dioica) has the antiandrogen palmetic
acid as an active component within the herb. Antihyperglycemic and
hypoglycemic effects has also been noted in Urtica dioica. Anti-inflammatory, analgesic and
antioxidant properties have also been attributed to Urtica dioica., which may contribute to its
beneficial properties.♦ |
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Holy Basil: Holy Basil
(Ocimum sanctum) leaf, with a long history of use in Ayurvedic Medicine,
contains antiandrogenic
properties that may be attributed to the presence of the 5-alpha-reductase inhibiting constituents; beta-sitosterol,
palmitic-acid and stearic-acid. In animal studies the
anti-androgenic property of Ocimum sanctum was shown to diminish response in
androgen sensitive tissues, an effect that was reversible two weeks after the
extract was stopped. Antihyperglycemic and hypoglycemic
effects has also been noted in Holy Basil. Animal studies have shown
Ocimum sanctum can cause lowering in serum total cholesterol, triglyceride, phospholipid and LDL-cholesterol levels and an increase
in the HDL-cholesterol. Sedative properties have been identified in Ocimum
sanctum as well as adaptogenic and antistressor properties in regard to
adverse stimuli and toxic substances. Ocimum sanctum has also been found to
inhibit acute as well as chronic inflammation in animal studies, which may
contribute to its antistress, adaptogenic properties.♦ |
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Fenugreek: Fenugreek (Trigonella foenum-graecum) seed has antiandrogenic properties due to
the presence of beta-sitosterol, palmitic-acid and stearic-acid. Beneficial anti-hyperglycemic
and hypoglycemic properties of Trigonella foenum-graecum have
been shown to decrease elevated glucose in a double blind placebo controlled human study. It has been shown
to reduce excessive glucose levels and increase the number of insulin
receptors in humans, possible by stimulating glucose-dependent insulin
secretion from pancreatic beta cells. Both human and animal studies have
shown fenugreek has the ability to lower total cholesterol, LDL, VLDL cholesterol
and triglycerides significantly. Anti-inflammatory properties have also been
documented in Trigonella foenum graecum, contributing to its beneficial
properties.♦ |
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Pygeum: Pygeum (Pygeum
africanum) bark
has the antiandrogen beta-sitosterol. Anti-inflammatory properties have been noted in
Pygeum africanum, contributing to the beneficial properties.♦ |
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References: |
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Ahmed
M, Ahamed RN, Aladakatti
RH, Ghosesawar MG. Reversible anti-fertility effect
of benzene extract of Ocimum sanctum leaves on sperm parameters and fructose
content in rats. J Basic Clin Physiol
Pharmacol. 2002;13(1):51-9. Ajabnoor MA, Tilmisany AK. Effect of Trigonella foenum graceum on blood
glucose levels in normal and alloxan-diabetic mice.
J Ethnopharmacol
1988;22:45-49. |
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Anon.
1948-1976. The Wealth of India raw materials. Publications and Information
Directorate, CSIR, Breu W, Hagenlocher
M, Redl K, Tittel G, Stadler F, Wagner H. [Anti-inflammatory activity of sabal fruit extracts prepared with supercritical carbon
dioxide. In vitro antagonists of cyclooxygenase and
5-lipoxygenase metabolism] Arzneimittelforschung.
1992 Apr;42(4):547-51. German. Collins, JJ. 2002. Discover
Your Menopause Type. Prima Publishing Collins, Joseph J.
2002. Discover Your Menopause Type. Prima Publishing Duke, James A. 1992.
Handbook of phytochemical constituents of GRAS herbs and other economic
plants. Godhwani S, Godhwani
JL, Vyas DS. Ocimum sanctum: an experimental study
evaluating its anti-inflammatory, analgesic and antipyretic activity in
animals. J Ethnopharmacol. 1987 Nov;21(2):153-63. |
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Gulcin I, Kufrevioglu
OI, Oktay M, Buyukokuroglu
ME. Antioxidant, antimicrobial, antiulcer and
analgesic activities of nettle (Urtica dioica L.). J Ethnopharmacol.
2004 Feb;90(2-3):205-15. Gupta A, Gupta R, Lal B. Effect of Trigonella foenum-graecum
(fenugreek) seeds on glycaemic control and insulin
resistance in type 2 diabetes mellitus: a double blind placebo controlled
study. J Assoc Physicians Hannan JM, Rokeya B, Faruque O, Nahar N, Mosihuzzaman M, Azad
Khan AK, Ali L. Effect of soluble dietary fibre
fraction of Trigonella foenum graecum on glycemic, insulinemic,
lipidemic and platelet aggregation status of Type 2
diabetic model rats. J Ethnopharmacol. 2003 Sep;88(1):73-7. |
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Javidnia K, Dastgheib
L, Mohammadi Samani S, Nasiri A. Antihirsutism activity
of Fennel (fruits of Foeniculum vulgare) extract. A double-blind placebo
controlled study. Phytomedicine. 2003;10(6-7):455-8. Kelm MA, Nair MG, Strasburg GM, DeWitt DL.
Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn. Phytomedicine. 2000 Mar;7(1):7-13. |
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Ng SS, Figg WD. Antitumor
activity of herbal supplements in human prostate cancer xenografts
implanted in immunodeficient mice. Anticancer Res. 2003
Sep-Oct;23(5A):3585-90. Paubert-Braquet M, Cave A, Hocquemiller R, Delacroix D, Dupont
C, Hedef N, Borgeat P.
Effect of Pygeum africanum extract on A23187-stimulated production of lipoxygenase metabolites from human polymorphonuclear
cells. J Lipid Mediat Cell Signal. 1994 May;9(3):285-90. Petit P, Sauvaire Y,
Ponsin G, Manteghetti M, Fave A, Ribes
G. Effects of a fenugreek seed extract on feeding behaviour
in the rat: metabolic-endocrine correlates. Pharmacol
Biochem Behav. 1993 Jun;45(2):369-74. |
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Prager N, Bickett K,
French N, Marcovici G. A randomized, double-blind,
placebo-controlled trial to determine the effectiveness of botanically
derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern
Complement Med. 2002 Apr;8(2):143-52. Raghuram TC, Sakina MR, Dandiya PC, Hamdard ME, Hameed A. Preliminary psychopharmacological evaluation of
Ocimum sanctum leaf extract. J Ethnopharmacol. 1990
Feb;28(2):143-50. Sarkar A, |
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Schulze-Tanzil G, de
SP, Behnke B, Klingelhoefer
S, Scheid A, Shakibaei M.
Effects of the antirheumatic remedy hox alpha--a new stinging nettle leaf extract--on matrix metalloproteinases in human chondrocytes
in vitro. Histol Histopathol.
2002 Apr;17(2):477-85. Sembulingam K, Sembulingam
P, Namasivayam A. Effect of Ocimum sanctum Linn on
noise induced changes in plasma corticosterone level.Indian
J Physiol Pharmacol. 1997
Apr;41(2):139-43. Sen P, Maiti
PC, Puri S, Ray A, Audulov
NA, Valdman AV Mechanism of anti-stress activity of
Ocimum sanctum Linn, eugenol and Tinospora malabarica in
experimental animals. Indian J Exp Biol. 1992 Jul;30(7):592-6. Sharma RD, Raghuram
TC, |
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Singh
S, Majumdar DK. Effect of Ocimum sanctum fixed oil
on vascular permeability and leucocytes migration. Indian J Exp Biol. 1999
Nov;37(11):1136-8. Stark
A, Madar Z. The effect of an ethanol extract
derived from fenugreek (Trigonella foenum-graecum) on bile acid absorption
and cholesterol levels in rats.Br J Nutr. 1993 Jan;69(1):277-87. Sur P, Das M, Gomes A, Vedasiromoni
JR, Sahu NP, Banerjee S,
Sharma RM, Ganguly DK. Trigonella foenum graecum
(fenugreek) seed extract as an antineoplastic
agent. Phytother Res. 2001 May;15(3):257-9. Urman B, Pride SM, Yuen BH.
Elevated serum testosterone, hirsutism, and virilism
associated with combined androgen-estrogen hormone replacement therapy. Obstet Gynecol. 1991 Apr;77(4):595-8. |
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♦ These statements have not been evaluated by the
Food and Drug Administration. |
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Testo-Quench™ is a
Trademark of Douglas Laboratories. All Rights Reserved. |
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